By Irvin M. Modlin MD PhD FRCS(Ed) FRCS(E, George Sachs MD ChB DSc
This textbook explores the background, biology, and therapy of acid similar illnesses, together with gastric and duodenal ulcer sickness, gastroesophageal reflux affliction (GERD), and the position of H. pylori. The textual content deals thorough assurance of the subject material, with an in-depth historic and organic concentration. equivalent concentration is given to the biology and pharmacology of acid secretion and to the explicit affliction states of ulcers and GERD. This version is filled with new full-color clinical illustrations of all features of this topic.
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Additional info for Acid Related Diseases: Biology and Treatment
Occlusion was demonstrated directly by showing 86Rb binding to the enzyme at a low temperature that was released by the addition of ATP. The addition of K+ to the enzyme-bound acylphosphate results in a two-step dephosphorylation. The faster initial step is dependent on the concentration of K+. The second phase of EP breakdown is accelerated in the presence of K+, but at K+ concentrations exceeding 500 μM, the rate becomes independent of K+ concentration. This shows that two forms of EP exist. The first form, E1P, is K+ insensitive and converts spontaneously to E2P, the K+-sensitive form.
How old is hydrochloric acid? Chymia 1965;10:11-23. Reuben MA, Lasater LS, Sachs G. Characterization of a beta subunit of the gastric H+/K(+)-transporting ATPase. Proc Natl Acad Sci U S A 1990;87:6767-6771. Sachs G, Chang HH, Rabon E, et al. A nonelectrogenic H+ pump in plasma membranes of hog stomach. J Biol Chem 1976;251:7690-7698. Schertler GFX, Villa C, Henderson R. Projection structure of rhodopsin. Nature 1993;362:770-772. Scott DR, Helander HF, Hersey SJ, et al. The site of acid secretion in the mammalian parietal cell.
In 1797, Jacob Anton Helm of Vienna studied a 58-year-old woman, Therese Petz of Breitenwaida, who had a spontaneous gastric fistula. Using a hired person, Zyriak Sieddeler, and himself, with his own brother as a control, Helm performed meticulous studies of digestion, intragastric temperature, and salivary function. Helm had no skills in chemistry, and he did not measure acid, nor was he able to demonstrate a change in the color of dye to indicate the presence of acid. Alexis St. Martin at the age of 67 years (inset).